The most popular problems of pharmaceutical packag

2022-08-07
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The problem of pharmaceutical packaging

with the continuous development of the pharmaceutical market, the pharmaceutical packaging market has also undergone profound changes. The external packaging of drugs is becoming more and more exquisite and lightweight, greatly facilitating the drug use needs of clinical and consumers. However, in our daily life, we often encounter problems caused by packaging, which causes waste of drug resources and economic losses

the label design should be standardized

the label of the injection is too large, accounting for more than 80% of the surface area of the drug bottle, and the color is too bright. In addition, the outer packaging is simple, and the drug name on the ampoule is not clear or easy to fall off. This phenomenon is common. Whether the color of the liquid is normal or not cannot be determined before using it to the patient, and the abnormal conditions of the liquid, such as mold, fiber, color spot and white spot, especially the small crack in the bottle body, have seriously affected the nursing quality and caused unnecessary medical disputes

it is suggested that the label design of the drug manufacturer should be standardized. Generally, the size should be 30% ~ 40% of the surface area of the drug bottle, and it should not be surrounded in a circular way, so as to facilitate the observation of the color and quality of the drug itself; Imported drugs have not only the instructions in Chinese, but also the labels. The most conspicuous names should be Chinese names rather than foreign names

the instructions shall be accurate and perfect

according to the provisions of the drug administration law, the drugs must be attached with instructions, which shall contain the name, specification, approval number, product batch number, expiry date, main description, indications, usage, dosage, contraindications, adverse reactions and precautions of the drugs

some instructions have production batch number, but the batch number is printed on the side of the kit or other parts, and is not fixed in the production batch number item of the instructions. The expiration date of some manuals, medicine boxes and labels is expressed by "exp date". It is difficult for those who do not know foreign languages to know the expiration date. Generally, the validity period is indicated by the number of years of use. The user must calculate whether the drug is invalid, which is very inconvenient in the process of use. It is recommended that the validity period be indicated as "to a certain day, a certain month, a certain year". The instructions of many slow-release tablets do not describe the use method in detail. Some patients can not slow down and control the release after chewing and taking them, and even cause the "peak response" phenomenon due to high blood drug concentration, resulting in side effects and even poisoning

the drug instruction manual is an important basis to guide the safe use of drugs and avoid mistakes and accidents. It has legal significance in medicine. The contents of drug instructions required by countries all over the world. For example, the instructions of enalapril capsules made in Australia include 17 items, such as product name, structural formula, properties, pharmacological effects, absorption, distribution, elimination, indications, usage and dosage, taboos, adverse reactions, precautions, specifications, packaging, storage, and service life, which are of reference value for drug use. However, most of the drug instructions produced in China have only 5 items, which is too simple. In order to make the drug packaging in line with international standards and to understand the use of drugs more clearly, the drug instructions should be detailed and truly achieve the purpose of guiding rational drug use

drug packaging should consider the needs of special groups

special groups refer to children and the elderly. However, this huge drug consumption group has a common phenomenon in clinical medication for a long time, that is, adult drugs are divided into therapeutic drugs. This method of medication, on the one hand, increases the chance of pollution; On the other hand, the surplus drugs can not be preserved but only discarded, resulting in a waste of drug resources and increasing the economic burden of patients. Therefore, the clinical medication should not be divided into adult drug doses simply by reference to age and weight. If the nurse is careless in the operation process, the dose will be difficult to be accurate or the drug will be wasted. In addition, the split use of drugs is easy to lose some specific effects of drugs, such as protection, controlled release, isolation, etc., which not only reduces the therapeutic effect of drugs, but also aggravates the adverse reactions of drugs. This serious packaging lag is extremely unfavorable to the drug demand of clinical children, and is also incompatible with the drug demand of China's elderly society, which accounts for 10% of the population. Therefore, it is urgent to develop new varieties, dosage forms and specifications suitable for children and the elderly

"dosage and usage" should be replaced by "reference usage" in the drug instructions and packaging. At present, many drugs have exquisite and gorgeous packaging, but they are not practical, which is not conducive to ensuring the quality of pharmaceutical care, nor to the proper medication of patients, and brings inconvenience to the medication guidance of patients and professionals. Therefore, when pharmaceutical enterprises compete to pass the GMP certification, it is necessary to further standardize the packaging and description of their drugs

the "usage and dosage" in the vast majority of drug instructions are: "how many Mg (g or tablets, granules) per time, how many times per day", which is a very clear statement, while some are more careful and give a range. In fact, the item "usage and dosage" can be changed to "reference usage" to avoid misleading patients. Because of the individual differences of patients and the specific metabolism of drugs, the blood concentration of drugs in the human body will change greatly

clearly marked dose

both traditional Chinese medicine and Western medicine should have marked dose. There are many drug specifications that do not specify the dosage of a unit drug, that is, the dose of the drug, mainly the majority of Chinese and Western medicine composite preparations and traditional Chinese medicine. In fact, pure traditional Chinese medicine preparations should also explain the content of their original traditional Chinese medicine as much as possible, so that professionals can analyze possible problems when serving patients, and better ensure rational drug use. In addition, the excipients of the preparation used shall be clearly stated in the drug description, because the excipients may also have effects or adverse reactions on human body

the front printing of the outer packaging needs to be standardized urgently

at present, there are many problems in the outer packaging of drugs, because the main items are printed in a disordered order and the listed items are in a fuzzy order, which is inconvenient for the drug users and pharmaceutical workers. There are many drug trade names and generic names that are similar to the font size of their functions. They are closely arranged and easy to mix together. It is difficult to distinguish the exact names of drugs, resulting in confusion when doctors prescribe prescriptions and often write wrong drug names. Many medicines are not clearly marked with the dosage and quantity on the front packaging, but are printed in remote places with too small font size. Although the items listed on the front of the outer packaging of many drugs are relatively complete, their positions are arranged in a disorderly manner, and the size and clarity of the drug dosage and quantity are not enough

therefore, it is necessary to improve the following contents: indicate the dosage form of the drug in a prominent position on the front, such as sustained-release preparations, capsules, enteric coated tablets, etc., because breaking off the drug administration can affect the absorption and activity of the active ingredients, while children and the elderly often use the drug C. full active fixture: the dosage of the drug needs to be adjusted from the sample size measurement to the clamping; A doctor's order position shall be reserved at the obvious place on the front, and the words "() times a day, () tablets each time" shall be printed. This will help to improve work efficiency, reduce waste, and provide convenience for patients' medication and services for pharmacists and doctors

in addition, due to the increase of foreign exchanges, the contents of the outer packaging of drugs should also be convenient for foreigners. It is recommended to write Chinese on the front and English on the back. Do not mix English and Chinese together. At present, its usage does not meet the requirements of gb/t228.1 (2) 010 standard; The electro-hydraulic servo universal experimental machine, indications, batch number, etc. can be written on the side, so that the primary and secondary are clear, convenient and practical

reprinted from: Guangdong packaging

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